synthesis and pharmacological evaluation of thiazolidinediones




Oleg Kolodiazhnyi I. Asymmetric Synthesis in Organophosphorus Chemistry. Synthetic Methods, Catalysis and Applications

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Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications. As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal-, organo- and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds. Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous-containing drugs.

Sharlene Hesse-Biber Mixed Methods and Credibility of Evidence in Evaluation. New Directions for Evaluation, Number 138

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Mixed methods in evaluation have the potential to enhance the credibility of evaluation and the outcomes of evaluation. This issue explores advances in understanding mixed methods in philosophical, theoretical, and methodological terms and presents specific illustrations of the application of these concepts in evaluation practice. Leading thinkers in the mixed methods evaluation community provide frameworks and strategies that are associated with improving the probability of reaching the goals of enhanced credibility for evaluations, the evidence they produce, and the actions taken as a result of the evaluation findings. This is the 138th volume of the Jossey-Bass quarterly report series New Directions for Evaluation, an official publication of the American Evaluation Association.

Sandra Mathison Really New Directions in Evaluation: Young Evaluators' Perspectives. New Directions for Evaluation, Number 131

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This issue of New Directions for Evaluation (NDE) marks a milestone: the 25th anniversary of the American Evaluation Association (AEA). NDE is an official publication of AEA and has been a crucial means for the Association to foster and promote the professionalization of evaluation through thematic discussions of theory and practice in evaluation. NDE was first published in 1978 under the name New Directions for Program Evaluation, although the title became New Directions for Evaluation in 1995 in acknowledgement of the broader scope of evaluation.

Sandra Mathison Really New Directions in Evaluation: Young Evaluators' Perspectives. New Directions for Evaluation, Number 131

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This issue of New Directions for Evaluation (NDE) marks a milestone: the 25th anniversary of the American Evaluation Association (AEA). NDE is an official publication of AEA and has been a crucial means for the Association to foster and promote the professionalization of evaluation through thematic discussions of theory and practice in evaluation. NDE was first published in 1978 under the name New Directions for Program Evaluation, although the title became New Directions for Evaluation in 1995 in acknowledgement of the broader scope of evaluation.

Nielsen Steffen Bohni Performance Management and Evaluation. New Directions for Evaluation, Number 137

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This issue focuses on connections between performance management and evaluation, a contentious topic at the moment. It does so by placing evaluation and monitoring under the overarching concept of performance management, and then by investigating five complementarities between performance monitoring and measurement on the one hand, and evaluation on the other. These complementarities are: Sequential Informational Organizational Methodical Hierarchical. Several case studies discuss the uses and complementarities of evaluation and performance management in contexts including national and local governments and the work of government, philanthropic foundations, and a direct-service nonprofit agency. These cases illustrate the advantages and pitfalls in utilizing evaluative approaches within the context of performance management. This is the 137th volume of the Jossey-Bass quarterly report series New Directions for Evaluation, an official publication of the American Evaluation Association.

Dean Spaulding T. Program Evaluation in Practice. Core Concepts and Examples for Discussion and Analysis

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An updated guide to the core concepts of program evaluation This updated edition of Program Evaluation in Practice covers the core concepts of program evaluation and uses case studies to touch on real-world issues that arise when conducting an evaluation project. This important resource is filled with illustrative examples written in accessible terms and provides a wide variety of evaluation projects that can be used for discussion, analysis, and reflection. The book addresses foundations and theories of evaluation, tools and methods for collecting data, writing of reports, and the sharing of findings. The discussion questions and class activities at the end of each chapter are designed to help process the information in that chapter and to integrate the information from the other chapters, thus facilitating the learning process. As useful for students as it is for evaluators in training, Program Evaluation in Practice is a must-have text for those aspiring to be effective evaluators. Includes expanded discussion of basic theories and approaches to program evaluation Features a new chapter on objective-based evaluation and a new section on ethics in program evaluation Provides more detailed information and in-depth description for each case, including evaluation approaches, fresh references, new readings, and the new Joint Committee Standards for Evaluation

Dutwin Phyllis The ABCs of Evaluation. Timeless Techniques for Program and Project Managers

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Thoroughly revised and updated, the third edition of bestselling The ABCs of Evaluation offers an introduction to program evaluation. This comprehensive textbook covers topics such as stakeholder relationships, program design, data collection and analysis, reporting results, and other important steps in the evaluation process. The ABCs of Evaluation shows how to select participants for the evaluation and how to deal with multiple goals and objectives—including those of the organization, the staff, and the client. The authors illustrate the circumstances under which each evaluation model can be used, and offer tips on identifying data sources and collecting the data. This revision includes substantially increased coverage of theory, methodological approaches, the business of evaluation, the evaluator's role and responsibilities, RFPs and the grants process, logic models, data analysis, and writing the evaluation report. Also included are new cases and scenarios from various evaluation realms in social sciences, education, health, and human services. Throughout the book, charts, graphs, models, and lists help organize, extend, and facilitate the understanding of each evaluation concept. Praise for the Previous Edition of The ABCs of Evaluation «A useful general overview of the evaluation process. I would recommend it to program or project managers wanting to know more about the process of evaluation.» —American Journal of Evaluation «All students (and practitioners) should have this in their library; they will use it frequently.» —Patricia McGee, PhD, associate professor, University of Texas, San Antonio Companion Web site: www.josseybass.com/go/Boulmetis

Stufflebeam Daniel L. Evaluation Theory, Models, and Applications

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The golden standard evaluation reference text Now in its second edition, Evaluation Theory, Models, and Applications is the vital text on evaluation models, perfect for classroom use as a textbook, and as a professional evaluation reference. The book begins with an overview of the evaluation field and program evaluation standards, and proceeds to cover the most widely used evaluation approaches. With new evaluation designs and the inclusion of the latest literature from the field, this Second Edition is an essential update for professionals and students who want to stay current. Understanding and choosing evaluation approaches is critical to many professions, and Evaluation Theory, Models, and Applications, Second Edition is the benchmark evaluation guide. Authors Daniel L. Stufflebeam and Chris L. S. Coryn, widely considered experts in the evaluation field, introduce and describe 23 program evaluation approaches, including, new to this edition, transformative evaluation, participatory evaluation, consumer feedback, and meta-analysis. Evaluation Theory, Models, and Applications, Second Edition facilitates the process of planning, conducting, and assessing program evaluations. The highlighted evaluation approaches include: Experimental and quasi-experimental design evaluations Daniel L. Stufflebeam's CIPP Model Michael Scriven's Consumer-Oriented Evaluation Michael Patton's Utilization-Focused Evaluation Robert Stake's Responsive/Stakeholder-Centered Evaluation Case Study Evaluation Key readings listed at the end of each chapter direct readers to the most important references for each topic. Learning objectives, review questions, student exercises, and instructor support materials complete the collection of tools. Choosing from evaluation approaches can be an overwhelming process, but Evaluation Theory, Models, and Applications, Second Edition updates the core evaluation concepts with the latest research, making this complex field accessible in just one book.

Karsten Schrör Acetylsalicylic Acid

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Written by a leading expert on Aspirin-related research, this is the most comprehensive treatise on the pharmacological effects and clinical applications of one of the most successful drugs ever. The text is written with a wide audience in mind, and to be readily understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike. This second, completely revised edition contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention from cardiovascular diseases and colorectal cancer.

Lam Yulin Solid-Phase Organic Synthesis. Concepts, Strategies, and Applications

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Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.

Kathy Lu Advances in Synthesis, Processing, and Applications of Nanostructures

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With contributed papers from the 2011 Materials Science and Technology symposia, this is a useful one-stop resource for understanding the most important issues in advances in the synthesis, processing, and applications of nanostructures. Logically organized and carefully selected, the articles cover the themes of the symposia: Nanotechnology for Energy, Healthcare and Industry; Controlled Synthesis Processing and Applications of Structural and Functional Nanomaterials; and Synthesis, Properties, and Applications of Noble Metal Nanostructures. A must for academics in mechanical and chemical engineering, materials and or ceramics, and chemistry.

Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids

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Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.

Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators

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Many small molecules occur naturally as «messenger» chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.

Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators

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Many small molecules occur naturally as «messenger» chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.

David Williams D. Seven North American Evaluation Pioneers. New Directions for Evaluation, Number 150

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How do people evaluate in daily life? This issue broaches this topic to better understand this dimension of being human, to develop evaluation theory, and to improve extraprofessional and professional evaluation practice. As part of a larger study addressing these issues in the lives of many professional evaluators around the world, case studies of seven early evaluation theorists and practitioners from North America were conducted. This issue contains articles with stories of some of their evaluation life experiences told and interpreted by these individuals, with commentary by an eighth evaluator. Themes that cross the cases are proposed, and responses by the individuals highlighted are shared in a final article. This is the 150th issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Johnson Douglas S. Modern Drug Synthesis

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Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

Barbara Rosenstein Evaluation and Social Justice in Complex Sociopolitical Contexts. New Directions for Evaluation, Number 146

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This volume is devoted to the theme of social responsibility, social justice, and evaluation. It examines the evaluation–social justice interface and: shares a variety of options and examples from different settings, gives voice to populations whose voices are rarely heard, and contributes to fulfilling the potential of the significant role evaluation can have in promoting social change. First discussing issues related to evaluation, social responsibility, social justice, and marginalized populations in general, it goes on to address issues concerning populations marginalized due to health, psychological, and physical difficulties; their cultural or ethnic/national status; or the specific geopolitical context of Israel. This is the 146th issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Xiao-Feng Wu Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation

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Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.

Baron Michelle E. Internal Evaluation in the 21st Century. New Directions for Evaluation, Number 132

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Nowadays, a considerable amount of evaluation work is implemented internally—both nationally and across the world. As such, it is exceedingly important for evaluators and organizations to be aware of the issues in designing and implementing internal evaluation to realize its potential for enhancing organizational growth, competitive advantage, and social impact. This issue includes perspectives on internal evaluation from experienced evaluation practitioners from different fields and organizations who share theoretical and practical examples and case studies in promoting and conducting internal evaluation. The chapters: Highlight societal and organizational changes that have shaped the current trends in internal evaluation Discuss foundational issues in internal evaluation Provide rich illustrations of internal evaluation practice in different settings with diverse foci (customer-driven vision and a results-based orientation for evaluation, accountability and development, and building evaluation capacity). This is the 132nd volume of the Jossey-Bass quarterly report series New Directions for Evaluation, an official publication of the American Evaluation Association.

Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action

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An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Moseley James L. Handbook of Improving Performance in the Workplace, Measurement and Evaluation

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HANDBOOK of IMPROVING PERFORMANCE IN THE WORKPLACE Volume 3: Measurement and Evaluation Volume Three of the Handbook of Improving Performance in the Workplace focuses on Measurement and Evaluation and represents an invaluable addition to the literature that supports the field and practice of Instructional Systems Design. With contributions from leading national scholars and practitioners, this volume is filled with information on time-tested theories, leading-edge research, developments, and applications and provides a comprehensive review of the most pertinent information available on critical topics, including: Measuring and Evaluating Learning and Performance, Designing Evaluation, Qualitative and Quantitative Performance Measurements, Evidence-based Performance Measurements, Analyzing Data, Planning Performance Measurement and Evaluation, Strategies for Implementation, Business Evaluation Strategy, Measurement and Evaluation in Non-Profit Sectors, among many others. It also contains illustrative case studies and performance support tools. Sponsored by International Society for Performance Improvement (ISPI), the Handbook of Improving Performance in the Workplace, three-volume reference, covers three core areas of interest including Instructional Design and Training Delivery, Selecting and Implementing Performance Interventions, and Measurement and Evaluation.

Pher Andersson G. Innovative Catalysis in Organic Synthesis. Oxidation, Hydrogenation, and C-X Bond Forming Reactions

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C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry. The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.

Leslie Goodyear Qualitative Inquiry in Evaluation. From Theory to Practice

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Integrate qualitative inquiry approaches and methods into the practice of evaluation Qualitative inquiry can have a major effect on evaluation practice, and provides evaluators a means to explore and examine various settings and contexts in need of rich description and deeper understanding. Qualitative Inquiry in Evaluation: From Theory to Practice explores the most important considerations for both students and evaluation professionals. Using various evaluation theories and approaches as a springboard for real-world practice, this reference serves as an accessible text for beginning students and seasoned professionals alike. Readers are given an in-depth view of the key qualities and benefits of qualitative inquiry, which also serves as a crucial counterpart to quantitative analysis. Chapters in part one focus on the foundations, core concepts, and intersection of evaluation theory and qualitative inquiry. Part two contains contributions from leading evaluators whose design, implementation, and reporting strategies for qualitative inquiry are centered on common, real-world settings. These case-based chapters point to the strengths and challenges of implementing qualitative evaluations. Key competencies for conducting effective qualitative evaluations are also discussed. Explores the role of qualitative inquiry in many prominent approaches to evaluation Discusses the method's history and delves into key concepts in qualitative inquiry and evaluation Helps readers understand which qualities are necessary to be an effective qualitative evaluator Presents the viewpoints and experiences of expert editors and contributing authors with high levels of understanding on the topic Qualitative Inquiry in Evaluation: From Theory to Practice is a vital tool for evaluators and students alike who are looking to deepen their understanding of the theoretical perspectives and practice considerations of qualitative evaluation.

Obaidat Mohammed S. Fundamentals of Performance Evaluation of Computer and Telecommunications Systems

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The only singular, all-encompassing textbook on state-of-the-art technical performance evaluation Fundamentals of Performance Evaluation of Computer and Telecommunication Systems uniquely presents all techniques of performance evaluation of computers systems, communication networks, and telecommunications in a balanced manner. Written by the renowned Professor Mohammad S. Obaidat and his coauthor Professor Noureddine Boudriga, it is also the only resource to treat computer and telecommunication systems as inseparable issues. The authors explain the basic concepts of performance evaluation, applications, performance evaluation metrics, workload types, benchmarking, and characterization of workload. This is followed by a review of the basics of probability theory, and then, the main techniques for performance evaluation—namely measurement, simulation, and analytic modeling—with case studies and examples. Contains the practical and applicable knowledge necessary for a successful performance evaluation in a balanced approach Reviews measurement tools, benchmark programs, design of experiments, traffic models, basics of queueing theory, and operational and mean value analysis Covers the techniques for validation and verification of simulation as well as random number generation, random variate generation, and testing with examples Features numerous examples and case studies, as well as exercises and problems for use as homework or programming assignments Fundamentals of Performance Evaluation of Computer and Telecommunication Systems is an ideal textbook for graduate students in computer science, electrical engineering, computer engineering, and information sciences, technology, and systems. It is also an excellent reference for practicing engineers and scientists.

Laurie Starkey S. Introduction to Strategies for Organic Synthesis

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The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.

Montrosse-Moorhead Bianca Revisiting Truth, Beauty,and Justice: Evaluating With Validity in the 21st Century. New Directions for Evaluation, Number 142

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This issue discusses ways of constructing, organizing, and managing arguments for evaluation. Not focued solely on the logic of evaluation or predictive validity, it discusses the various elements needed to construct evaluation arguments that are compelling and influential by virtue of the truth, beauty, and justice they express. Through exposition, original research, critical reflection, and application to case examples, the authors present tools, perspectives, and guides to help evaluators navigate the complex contexts of evaluation in the 21st century. This is the 142nd issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery

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Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.

Andrea Trabocchi Diversity-Oriented Synthesis. Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology

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Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.

Cousins J. Bradley Organizational Capacity to Do and Use Evaluation. New Directions for Evaluation, Number 141

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Gain a greater understanding of organizational capacity to do and use evaluation and implications for evaluation capacity building (ECB). This volume is unique in that it represents a multiple case study of eight organizations that were committed to ECB. It: Situates the study in terms of ECB theory and research Delineates a conceptual framework Presents case profile reports and the results of a cross-case analysis. Discusses findings in terms of implications for research, theory, and practice. This is the 141st issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Giacalone Francesco Catalytic Methods in Asymmetric Synthesis. Advanced Materials, Techniques, and Applications

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This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.

Michael Patton Quinn Pedagogy of Evaluation. New Directions for Evaluation, Number 155

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As pedagogy is the study of teaching, pedagogy of evaluation examines how and what evaluation teaches. This volume is inspired by the works of Paulo Freire who believed that all interactions between people are pedagogical: something is always being taught, conveyed, and proselytized (the same could be said of evaluation). Freirean principles, though articulated nearly 50 years ago, offer and affirm future directions for dealing with inequality, poverty, social injustice, community development, education, and, to the point here, evaluation. The principles remain fresh and timely, and new. Divided into three parts, the editors invite you to use Freire?s works to reflect on your pedagogy of evaluation. Contemporaries of Paulo Freire present his pedagogy Pedagogical principles of evaluation derived from Freire Freire?s current evaluation influence illustrated This is the 155th issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Muriel Harris J. Evaluating Public and Community Health Programs

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A practical introduction to participatory program evaluation Evaluating Public and Community Health Programs provides a comprehensive introduction to the theory and practice of evaluation, with a participatory model that brings stakeholders together for the good of the program. Linking community assessment, program implementation, and program evaluation, this book emphasizes practical, ongoing evaluation strategies that connect theory with application. This updated second edition includes new discussion on planning policy change programs using logic models and theory of change, plus expanded coverage of processes, outcomes, data collection, and more. Each chapter includes classroom activities and group discussion prompts, and the companion website provides worksheets, lecture slides, and a test bank for instructors. Mini cases help illustrate the real-world applications of the methods described, and expanded case studies allow students to dig deeper into practice and apply what they've learned. Accurate and effective evaluation is the key to a successful program. This book provides a thorough introduction to all aspects of this critical function, with a wealth of opportunities to apply new concepts. Learn evaluation strategies that involve all program stakeholders Link theory to practice with new mini cases and examples Understand the uses, processes, and approaches to evaluation Discover how ongoing evaluation increases program effectiveness Public and community health programs are a vital part of our social infrastructure, and the more effective they are, the more people they can serve. Proper planning is important, but continued evaluation is what keeps a program on track for the long term. Evaluating Public and Community Health Programs provides clear instruction and insightful discussion on the many facets of evaluation, with a central focus on real-world service.

Cossy Janine Modern Tools for the Synthesis of Complex Bioactive Molecules

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All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements and domino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags and engineered biosynthesis The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.

Kushner Saville Evaluation Voices from Latin America. New Directions for Evaluation, Number 134

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Hear from evaluation practitioners throughout Latin America. In this region program evaluation is an emergent practice, one that is shaped by distinctive geopolitical and social contexts and has its own intellectual biography. Through a selection of writings and cases this issue provides a window on program evaluation in this region. The articles indicate a range of experiences and concerns that respond to the countries’ unique histories and cultures. Articles by evaluators from Argentina, Brazil, Chile, Colombia, Costa Rica, and Peru illustrate new directions and are grouped around the following themes: Strategic use of evaluation in public policies and active citizenship Innovative project evaluation examples Evaluation capacity building and institutionalization. The widespread development of participatory or actor-oriented approaches, based on qualitative methodologies that have a particularly Latin American stamp, are emphasized in this issue. This is the 134th volume of the Jossey-Bass quarterly report series New Directions for Evaluation, an official publication of the American Evaluation Association.

Moira Inkelas Improvement Science in Evaluation: Methods and Uses. New Directions for Evaluation, Number 153

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While improvement science has experienced a surge of interest over the past 30 years, applications of it are rare in the evaluation literature. This issue promotes the cross-fertilization of ideas, techniques, and tools between evaluation and improvement science. There are at least four areas where this cross-fertilization is particularly relevant: learning from error, examining variation, appreciating context, and focusing on systems change. This volume considers: the conceptual similarities and distinctions between improvement science and evaluation; the intellectual foundations, methods, and tools that collectively comprise improvement science; and case chapters that offer an inspiring review of state-of-the-art improvement science applications. Cutting across all of these applications is a shared grounding in systems thinking, a determination to capture and better understand variation and contextual complexity, as well as a sustained commitment to generative learning about projects and programs—all issues of great concern to evaluators. The issue offers producers and users of evaluations the potential benefits of a closer engagement with improvement science. This is the 153rd issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication ofthe American Evaluation Association.

Dominique Estampe Supply Chain Performance and Evaluation Models

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This book presents the different models of supply chain performance evaluation for global supply chains. It describes why it is necessary to evaluate global performance both to assess the contribution of the supply chain to achieve the goals of creating value throughout the chain and also to meet customer requirements in terms of time, responsiveness and reliability. The author provides an understanding of how evaluation models are chosen according to criteria including the level of maturity of the organization, the level of decision-making and the level of value creation desired.

Srinivasan Chandrasekaran Click Reactions in Organic Synthesis

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This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.

Craig Adam Forensic Evidence in Court. Evaluation and Scientific Opinion

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The interpretation and evaluation of scientific evidence and its presentation in a court of law is central both to the role of the forensic scientist as an expert witness and to the interests of justice. This book aims to provide a thorough and detailed discussion of the principles and practice of evidence interpretation and evaluation by using real cases by way of illustration. The presentation is appropriate for students of forensic science or related disciplines at advanced undergraduate and master's level or for practitioners engaged in continuing professional development activity. The book is structured in three sections. The first sets the scene by describing and debating the issues around the admissibility and reliability of scientific evidence presented to the court. In the second section, the principles underpinning interpretation and evaluation are explained, including discussion of those formal statistical methods founded on Bayesian inference. The following chapters present perspectives on the evaluation and presentation of evidence in the context of a single type or class of scientific evidence, from DNA to the analysis of documents. For each, the science underpinning the analysis and interpretation of the forensic materials is explained, followed by the presentation of cases which illustrate the variety of approaches that have been taken in providing expert scientific opinion.

Stewart Donaldson I. Advancing Validity in Outcome Evaluation: Theory and Practice. New Directions for Evaluation, Number 130

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Exploring the influence and application of Campbellian validity typology in the theory and practice of outcome evaluation, this volume addresses the strengths and weaknesses of this often controversial evaluation method and presents new perspectives for its use. Editors Huey T. Chen, Stewart I. Donaldson and Melvin M. Mark provide a historical overview of the Campbellian typology adoption, contributions and criticism. Contributing authors propose strategies in developing a new perspective of validity typology for advancing validity in program evaluation including Enhance External Validity Enhance Precision by Reclassifying the Campbellian Typology Expand the Scope of the Typology The volume concludes with William R. Shadish's spirited rebuttal to earlier chapters. A collaborator with Don Campbell, Shadish provides a balance to the perspective of the issue with a clarification and defense of Campbell's work. This is the 129th volume of the Jossey-Bass quarterly report series New Directions for Evaluation, an official publication of the American Evaluation Association.

Shinichi Itsuno Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis

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This book reviews chiral polymer synthesis and its application to asymmetric catalysis. It features the design and use of polymer-immobilized catalysts and methods for their design and synthesis. Chapters cover peptide-catalyzed and enantioselective synthesis, optically-active polymers, and continuous flow processes. It collects recent advances in an important field of polymer and organic chemistry, with leading researchers explaining applications in academic and industry R & D.

Gongkang Fu Bridge Design and Evaluation. LRFD and LRFR

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A succinct, real-world approach to complete bridge system design and evaluation Load and Resistance Factor Design (LRFD) and Load and Resistance Factor Rating (LRFR) are design and evaluation methods that have replaced or offered alternatives to other traditional methods as the new standards for designing and load-rating U.S. highway bridges. Bridge Design and Evaluation covers complete bridge systems (substructure and superstructure) in one succinct, manageable package. It presents real-world bridge examples demonstrating both their design and evaluation using LRFD and LRFR. Designed for a 3- to 4-credit undergraduate or graduate-level course, it presents the fundamentals of the topic without expanding needlessly into advanced or specialized topics. Important features include: Exclusive focus on LRFD and LRFR Hundreds of photographs and figures of real bridges to connect the theoretical with the practical Design and evaluation examples from real bridges including actual bridge plans and drawings and design methodologies Numerous exercise problems Specific design for a 3- to 4-credit course at the undergraduate or graduate level The only bridge engineering textbook to cover the important topics of bridge evaluation and rating Bridge Design and Evaluation is the most up-to-date and inclusive introduction available for students in civil engineering specializing in structural and transportation engineering.

Jozo Dujmović Soft Computing Evaluation Logic. The LSP Decision Method and Its Applications

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A novel approach to decision engineering, with a verified framework for modeling human reasoning Soft Computing Evaluation Logic provides an in-depth examination of evaluation decision problems and presents comprehensive guidance toward the use of the Logic Scoring of Preference (LSP) method in modeling complex decision criteria. Fully aligned with current developments in computational intelligence, the discussion covers the design and use of LSP criteria for evaluation and comparison in diverse areas, such as search engines, medical conditions, real estate, space management, habitat mitigation projects in ecology, and land use and residential development suitability maps, with versatile transfer to other similar decision-modeling contexts. Human decision making is rife with fuzziness, imprecision, uncertainty, and half-truths—yet humans make evaluation decisions every day. In this book, such decision processes are observed, analyzed, and modeled. The result is graded logic, a soft computing mathematical infrastructure that provides both formal logic and semantic generalizations of classical Boolean logic. Graded logic is used for logic aggregation in the context of evaluation models consistent with observable properties of human reasoning. The LSP method, based on graded logic and logic aggregation, is a vital component of an industrial-strength decision engineering framework. Thus, the book: Provides detailed theoretical background for graded logic Provides a theory of logic aggregators Explains the LSP method for designing complex evaluation criteria and their use Shows techniques for evaluation, comparison, and selection of complex systems, as well as the cost/suitability analysis, optimization, sensitivity analysis, tradeoff analysis, and missingness-tolerant aggregation Includes a survey of available LSP software tools, including ISEE, ANSY and LSP.NT. With quantitative modeling of human reasoning, novel approaches to modeling decision criteria, and a verified decision engineering framework applicable to a broad array of applications, this book is an invaluable resource for graduate students, researchers, and practitioners working within the decision engineering realm.

Toshio Fuchigami Fundamentals and Applications of Organic Electrochemistry. Synthesis, Materials, Devices

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This textbook is an accessible overview of the broad field of organic electrochemistry, covering the fundamentals and applications of contemporary organic electrochemistry. The book begins with an introduction to the fundamental aspects of electrode electron transfer and methods for the electrochemical measurement of organic molecules. It then goes on to discuss organic electrosynthesis of molecules and macromolecules, including detailed experimental information for the electrochemical synthesis of organic compounds and conducting polymers. Later chapters highlight new methodology for organic electrochemical synthesis, for example electrolysis in ionic liquids, the application to organic electronic devices such as solar cells and LEDs, and examples of commercialized organic electrode processes. Appendices present useful supplementary information including experimental examples of organic electrosynthesis, and tables of physical data (redox potentials of various organic solvents and organic compounds and physical properties of various organic solvents).

Dennis Bours Monitoring and Evaluation of Climate Change Adaptation: A Review of the Landscape. New Directions for Evaluation, Number 147

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Monitoring and evaluation (M&E) of climate change adaptation (CCA) poses an assortment of thorny methodological challenges. Individually, none are unique to CCA, but together they represent a very distinctive conundrum facing practitioners and policy makers. Adding to this complexity further, climate change may be global in nature but its impacts, and how we respond to them through adaptation efforts, cut across scales, sectors, and levels of intervention. As investments in climate adaptation increase, organizations are seeking to measure, assess and understand an array of adaptation initiatives, and derive learnings to inform policy and praxis. This issue presents findings from many of the most important contemporary CCA program evaluation research initiatives. The chapters represent the most coherent and current collection of CCA M&E research in this emerging and important field, written by many of its leading experts. Filled with examples and insights in formulating coherent responses to methodological challenges, it will be of interest to M&E scholars and practitioners globally. This is the 147th issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Piet W. N. M. van Leeuwen Phosphorus(III) Ligands in Homogeneous Catalysis. Design and Synthesis

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Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals. This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis. Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation. Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands. Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice. Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry.

V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science

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The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.

Anna Schmidt Marie Effective Grant Writing and Program Evaluation for Human Service Professionals

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A state-of-the-art guide for developing grants witha strong emphasis on using program outcome measurement to underscore need and accountability Based on the authors' many years of experience in the public and nonprofit sectors, Effective Grant Writing and Program Evaluation for Human Service Professionals integrates the topics of grant proposal writing and program evaluation, offering grant seekers the practical guidance they need to develop quality proposals, obtain funding, and demonstrate service results and accountability. The authors clearly and succinctly illustrate and describe each stage of the grant writing and evaluation process. Problems or issues that arise frequently are highlighted and followed by specific advice. In addition, numerous real-world examples and exercises are included throughout the book to give readers the opportunity for reflection and practice. This timely reference incorporates a strengths perspective, providing: An inside look at the grant writing and evaluation processes, with insights from experienced grant writers, agency administrators, foundation program managers, and grant reviewers Specific examples of successful grant proposals and evaluation plans and instruments serving as models for learning and practice Field-tested individual and group exercises that facilitate the development of grant writing and evaluation skills Discussion of electronic technology in grant writing and evaluation, including writing and submitting grant proposals online, and identifying funding sources This grant writing and program evaluation guide follows a needs-driven, evidence-based, result-oriented, and client-centered perspective. Its authoritative discussion equips human service professionals to effectively develop grants with a strong emphasis on measuring program outcomes.

Monica Stitt-Bergh Evaluating Student Learning in Higher Education: Beyond the Public Rhetoric. New Directions for Evaluation, Number 151

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Evaluation has played a fundamental role throughout the history of higher education. It has been key to institutional missions and for accountability concerns for public funding policy and fiscal oversight. In the last 30 years, there has been focused attention on the quality of education and student learning. Campuses have stepped up their initiatives to evaluate educational outcomes—and communicate these to their constituencies—just as regional, state, and national efforts have emerged regarding assessment of learning outcomes. In this context, various methods and approaches to evaluative inquiry have emerged to support efforts to increase the effectiveness and efficiency of instructional practice and curriculum for higher learning. This edition examines perspectives on evaluation studies addressing higher education learning—from program- to institution-based studies and critiques of practice—to document successes and identify significant challenges that face evaluators and the collaborating educators in the continuing development of higher education. This examination represents both an investigation into the particular insights that evaluative inquiry contributes to the scholarship and practice of higher education and a reflection on the evaluation expertise that can be applied across contexts of professional practice and program development. This is the 151st issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

John Tebby C. Alkynes in Cycloadditions

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Acetylene systems present a new route to cyclic compounds as an alternative to more traditional methods employed in classical organic chemistry. The synthesis of cyclic structures based on acetylene systems has important applications in the formation of nanostructures, naturally occurring compounds and chemosensory materials for the design of nonlinear optics, electronic and photonic devices. Alkynes in Cycloadditions presents a modern review of regioselective synthesis of aromatic and non-aromatic carbocyclic and heterocyclic ring systems based primarily on [2+2+2] and [4+2] cycloadditions, and other reactions of acetylenic units including enediynes and enyne-allenes. Topics covered include: New strategies for the formation of aromatic and polynuclear hydrocarbons based on (Z)-hex-3-en-1,5-diyne and (Z)-hepta-1,2,4-triene-6-yne blocks. One-step synthesis of benzene derivatives, β-substituted naphthalenes and acenes by the cycloaromatization of enediynes and enyne-allenes by Bergman, Myers-Saito and Shmittel. Mechanisms of cycloaromatization resulting in the formation of fulvene and indene systems. Heterocyclization involving enyne-carbodiimides. New achievements in classical cycloaddition reactions such as the Diels-Alder condensation with acetylenic dienophiles and [2+2] cycloadditions with acetylene components Alkynes in Cycloadditions presents a comprehensive summary of the literature on methods for the synthesis of ring systems from acetylenes for academic researchers working in the fields of organic synthesis, physical organic chemistry, organometallic chemistry, catalysis, materials science, nanomaterials and biochemistry.

Paul Brandon R. Research on Evaluation. New Directions for Evaluation, Number 148

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This issue broaden the field’s understanding of Research on Evaluation (RoE) in practice, with a focus on empirical RoE. Considering the full collection of RoE studies, it defines RoE as systematic empirical inquiry resulting in original findings or in reexaminations of existing data about the practice, methods, or profession of program evaluation. RoE inquiries address: the inputs into evaluations, the contexts within which evaluations are conducted, the full range of methods and activities of evaluations, evaluation’s proximal or distal effects, or the professional issues that evaluators encounter. The inquiries include case studies, reflective narratives, studies about evaluation methods, literature reviews, oral histories, bibliometric studies, meta-evaluations, experiments, longitudinal studies, simulations, and time-series studies. This is the 148th issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Jie Jack Li Innovative Drug Synthesis

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This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

Wyatt Paul Workbook for Organic Synthesis: The Disconnection Approach

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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.

Anbanandam Parthiban Synthesis and Applications of Copolymers

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Understanding the reactivity of monomers is crucial in creating copolymers and determining the outcome of copolymerization. Covering the fundamental aspects of polymerization, Synthesis and Applications of Copolymers explores the reactivity of monomers and reaction conditions that ensure that the newly formed polymeric materials exhibit desired properties. Referencing a wide-range of disciplines, the book provides researchers, students, and scientists with the preparation of a diverse variety of copolymers and their recent developments, with a particular focus on copolymerization, crystallization, and techniques like nanoimprinting and micropatterning.

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

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This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Pagliaro Louis A. Handbook of Child and Adolescent Drug and Substance Abuse. Pharmacological, Developmental, and Clinical Considerations

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Selected by Choice as a 2013 Outstanding Academic Title

Andrushko Natalia Stereoselective Synthesis of Drugs and Natural Products

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Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Janine Cossy Metathesis in Natural Product Synthesis. Strategies, Substrates and Catalysts

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Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

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17405.46 руб. или Карта рассрочки!
This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Alissa Schwartz Evaluation and Facilitation. New Directions for Evaluation, Number 149

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Join the conversation between evaluation and facilitation. This issue explores the interplay between the two and how one practice can inform the other. The authors represent both the evaluation and facilitation fields, describing underlying concepts that inform their practices, the competencies they seek to develop, the choices they make about facilitation in the work they do, and how they gauge success. This issue brings together topics meant to stimulate the curiosity of evaluators and facilitators and encourage reflection on their work and the skills needed to carry it out. This is the 149th issue in the New Directions for Evaluation series from Jossey-Bass. It is an official publication of the American Evaluation Association.

Klaus Buchholz Biocatalysts and Enzyme Technology

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This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.

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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
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